Ingxenye yesine yesaga ye-Resident Evil isivele idutshulwa, ngokusekelwe kumdlalo wevidiyo odumile osinikeze izinto eziningi ezithusayo namahora okuzijabulisa.
Le ngxenye yesine inesihloko Isakhamuzi Esibi: Ngemuva kokufa futhi inolwazi lokuthi yamukela imfashini yamanje ye-3D.
Kubalingisi Milla Jovovich Uzophinde adlale indima yeqhawekazi elibulala ama-zombie, elihlanganiswe ngu-Ali Larter noSpencer Locke (obonwe ku-Resident Evil: Extinction). Abasha ngoWenworth Miller (ophuma ochungechungeni lwePrison Break) kanti kunamahlebezi okuthi umlingisi waseSpain uSergio Peris Mancheta naye uzobe ekhona.
Kule ngxenye yesine, u-Alice (Jovovich mile) qhubeka ufuna abantu abangathintwa igciwane kanye nama-Zombies aqothulayo. Endleleni yakhe ufika edolobheni lase-Los Angeles futhi uthole ukuthi ungenwe ama-Zombies.
Usuku lokukhishwa luhlelelwe u-Agasti 27, 2010.
Kimina, ikakhulukazi, ingxenye yokuqala yayibonakala ijabulisa kodwa ingxenye yesibili neyesithathu yayiyimbi kakhulu. Asethembe ukuthi le ngxenye yesine okungenani iyajabulisa futhi singajabulela ukubona ukuthi babulala kanjani amakhulukhulu ama-zombies.