Lapha sinesithombe sokuqala se- Jessica Alba kwezamahlaya «Spy Izingane 4«, omunye umkhiqizo kaRobert Rodríguez. Vuliwe "Spy Izingane 4«U-Alba nguMarissa Cortez Wilson, unkosikazi wentatheli yethelevishini nomama wezingane ezimbili, oyinhloli ethathe umhlalaphansi.
Lapho umgcini wesikhathi oyisikhohlakali (u-Jeremy Piven) eqala ukuthatha umhlaba, ubizwa futhi emsebenzini futhi izingane zakhe u-Rebekah (Rowan Blanchard) kanye no-Cecil (Mason Cook) balethwa esigabeni 'se-Spy Kids'.
Amahlaya nawo alingisi Antonio Banderas, Danny Trejo, Joel McHale y I-Alexa Vega futhi ukukhishwa kwayo kwethiyetha kuzoba ngo-Agasti 19.