Sasikholelwa ukuthi ifilimu I-Indiana Jones kanye noMbuso we-Crystal Skull, izokhishwa okokuqala emhlabeni jikelele, kodwa ngeke kube, ifilimu yesine ye-Indiana Jones izoqala ukuvela ngokuvula ifilimu. Cannes umkhosi el ngokulandelayo kwangama-18, ezinsukwini ezine ngaphambi kombukiso wayo wokuqala emhlabeni.
Njengokubuka kuqala futhi ngokusho kolwazi olufinyelele kwabezindaba, kwifilimu Indiana Jones Uzophoqeleka ukuthi asize ibutho leSoviet Army lifune ugebhezi lwekristalu oluyigugu olufihlwe ehlathini laseNingizimu Melika lapho lusongela impilo yentombi yakhe yakudala (Karen Allen), ongunina wengane yakhe (UShia LaBeouf).