Wainwright ya bayyana wa kundin aikin "mafi yawan pop" da ya yi a cikin aikinsa. An haife shi a ranar 22 ga Yuli, 1973 a Rhinebeck, New York, Rufus ɗan mawaƙan jama'a ne Loudon Wainwright III da Kate McGarrigle, kuma ɗan'uwan mawaƙa Martha Wainwright. Ya fara kunna piano yana ɗan shekara 6 kuma ya zagaya da iyalinsa yana ɗan shekara 13. Yayin da ya kai shekara 20 ya fara wasan solo.
'Daga Wasa'zai zama kundi na studio na bakwai, bayan' All Days Are Nights: Songs for Lulu', released in 2010. Kuma ga waɗanda ke zaune a Spain, mawaƙin zai nuna kayansa a cikin watanni masu zuwa: a ranar 4 ga Mayu zai kasance a ciki. Granada, a cikin dakin taro na Del Generalife; Yuni 1 a Barcelona, a San Miguel Primavera Sound Festival da kuma Yuni 6 a A Coruña a Opera Palace.